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A Brief History: From Abstinence-Only to Evidence-Based Pharmacotherapy The treatment of SUD has historically leaned heavily on abstinence and psychotherapy

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This is possible, but given that innate inflammation in the form of microglial activation and macrophage infiltration is a universal response to most types of CNS injury (Rivest, 2009), we would argue that it remains equally plausible that in MS microglia/macrophages are instead reacting to some persistent underlying pathological process in an attempt to limit and repair the expanding white matter damage

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doi: 10.1038/s41419-020-03020-9 121 ZhangHGaoYQiaoPFZhaoFLYanY